Induction of micronuclei in a transplantable murine tumor after multimodality treatment with cis-platin, radiation and hyperthermia
نویسندگان
چکیده
*Corresponding author: Prof. Satish Rao, BS, Division of Radiobiology & Toxicology, Manipal Life Sciences Center, Manipal University, Manipal 576 104, Karnataka, India. Fax: +91 82
منابع مشابه
Induction of micronuclei in a transplantable murine tumor after multimodality treatment with cis-platin, radiation and hyperthermia
Background: Tumor response after multimodality treatment using combination of radiation, chemotherapeutic drugs and hyperthermia usually assessed by parameters such as tumor growth delay, volume doubling time and regression response. The study herein was conducted to investigate the usefulness of micronucleus assay for assessing the multimodality treatment. Materials and Methods: The ...
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Response of a transplantable tumor, S180, grown intradermally in inbred Balb/c mice, was assessed by using micronucleus assay after treating the solid tumors with bleomycin (BLM), radiation (RT) and hyperthermia (HT) vis-a-vis multimodality approach. The frequency of micronuclei (MN) though did not vary greatly during the one week of observation in untreated tumors, it significantly increased i...
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